Senior Research Associate Invivo Pharmacology
Cambridge, MA Invivo Pharmacology
Job Type

Job Summary

In this role, you will be a key contributor in executing in vivo pharmacology studies in support of our preclinical pipeline within the Immunology and Preclinical Pharmacology group. These will include hands-on support of PK, PD, tumor efficacy as well as mechanistic studies also including support for ex vivo processing of samples in collaboration with other immunology team members.

 Responsibilities and Duties  

? Development and validation of rodent models of cancer 

? Design and perform in vivo efficacy studies including monitoring of disease progression and drug treatments

? Perform necropsies, harvest tissues and blood by alternate methods

? Evaluate pharmacodynamics using molecular, cell and protein techniques (flow cytometry, Western Blotting, ELISAs, MSD Immunohistochemistry and RT-PCR)

? Independently plan, execute, analyze and interpret data

? Present results in both written and in oral format



Preferred qualifications:

  • B.S in immunology, molecular cell biology or pharmacology, with greater than three years of relevant industry or academic experience
  • Proficiency with all minor and major surgeries in rodents
  • Hands-on experience with imaging techniques a plus 
  • Ability to work with team of immunologists to support ex vivo biomarker studies including flow cytometry, multiplex assays and standard immunoassays

Minimal requirements:

  • Bachelor's in Biology, with at least 3 years of relevant industry or academic experience
  • Hands-on experience in building and handling of murine disease models of cancer (syngeneic, xenograft)
  • Proficiency with administration in rodents via IV, IP, SC, IM and PO routes
  • Proficiency in collection of blood and murine tissues and necropsy
  • Strong communication and problem-solving skills and ability to thrive in a fast- paced and highly matrixed environment
  • Marengo is committed to treating all applicants fairly without discrimination. We welcome applications from all individuals, regardless of race, national origin, gender, age, physical characteristics, social origin, disability, union membership, religion, family status, pregnancy, sexual orientation, gender identity, gender expression or any unlawful criterion under applicable law.