Do you have the passion to join a group whose mission is to pioneer the discovery of a new class of medicines to treat diseases unaddressed by today’s therapies? Does it excite you to be a part of a company with a platform that can address any disease area with high unmet medical need? If yes, you may be a great fit to join Arrakis on our path to bring powerful new RNA-targeted small molecule (rSM) medicines to millions of patients.
Your Impact at Arrakis
The mission of Arrakis Therapeutics is to extend small molecule medicines into new realms of biology by discovering and developing compounds that selectively target RNA. By targeting distinct RNA structure: function relationships, Arrakis aims to generate drug candidates with novel mechanisms of action for molecular targets that are challenging to drug with other approaches, opening up vast new realms of human biology for medicine.
The Arrakis Discovery Biology team is seeking a talented Senior Research Associate to develop cell based assays. This individual will be a key player in a collaborative team effort to modulate expression of target proteins. Immediate goals will involve determining protein half-life and establishing cellular screening assays such as dual luciferase reporter (DLR) assays and other plate-based immuno-assays. The longer-term vision for growth opportunities in this role include assay development in primary cells, utilization of NGS techniques, and future potential for mentoring an intern/co-op or working with CROs. The ideal candidate will enjoy working in a collaborative, fast-paced start-up environment, leveraging a high degree of integrity, intelligence, and innovation to make a large impact on our mission. They will be part of a team with diverse roles in cell and molecular biology and may also collaborate with biochemistry, biophysics, and computational groups.
- With guidance, execute cell biology experiments to validate key aspects of target biology in mammalian cells on a timely basis to support internal programs and external collaboration efforts
- Culture a wide variety of immortalized and primary cells to support assay validation efforts
- Develop assays to assess target biology such as protein half-life (e.g. siRNA mediated protein knockdown)
- Develop screening and counterscreening formats such as HiBiT, DLR, MSD, ELISA, and HTRF
- Generate new and innovative approaches to technical challenges
- Carefully document experiments in an electronic lab notebook
- Present ideas and results, including issues & possible solutions, at small group and company-wide meetings
- Work effectively with a cross-functional biology, informatics, assay development and chemistry team to deliver high-quality results in an efficient manner
- B.S. in Cell Biology, Molecular Biology or Biology with some industry experience required
- Experience with general mammalian cell culture techniques required
- Experience/willingness to learn western blotting/WES, qPCR, MSD, HTRF, HiBiT, and CRISPR
- Experience/willingness to culture primary human PBMC and cellular isolates
- Experience/willingness to learn lentiviral production and transduction of mammalian cells
- Molecular biology and flow cytometry experience a plus
- Ability to effectively communicate methodologies and results with management and colleagues
- High level of integrity and good work ethic
- Strong sense of urgency embodied by rapid responses to changing priorities
- Highly organized with strong ability to multitask
- Exhibits passion and excitement over work. Has a can-do attitude without losing objectivity
- Keeps an open mind and is willing to apply creative solutions
- Fosters a positive work environment by collaborating with teammates and communicating with transparency
Interested in learning more about Arrakis? Click on the links below!
Arrakis/Amgen Partnership (Jan. 2022)
Arrakis/Roche Alliance Partnership (Apr. 2021)
Dark Matter Blog: Arrakis achieves escape velocity
Dark Matter Blog: Following our pole star
Arrakis is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive equal consideration for employment without regard to race, color, religion, national origin or ancestry, sex, pregnancy, sexual orientation, gender identity, age, disability, military service, veteran status, genetic information, or any other characteristic protected by law.