(Senior/Exec) Medical Director, Oncology

About Morphic Therapeutic

Morphic Therapeutic is a biopharmaceutical company developing a new generation of oral integrin therapies for the treatment of serious chronic diseases, including autoimmune, cardiovascular and metabolic diseases, fibrosis and cancer. In collaboration with Schrödinger, Morphic is advancing its pipeline and discovery activities using its proprietary MInT technology platform which leverages the Company’s unique understanding of integrin structure and biology. For more information, visit www.morphictx.com.Morphic is advancing both partnered and fully-owned oral integrin therapeutic candidates with the initial clinical trials beginning in 2020. Our immediate focus is on the areas where the clinical activity of antibody inhibitors of integrins is precedented, thus enabling a rapid path to clinical proof-of-concept. Morphic Therapeutic is located in the AstraZeneca BioHub in Waltham, MA. We are seeking a highly talented and motivated individual to join our culture of teamwork, craftsmanship, tenacity, compassion, integrity, and beauty. 


Job Description:

Responsibilities include, but are not limited to:

Morphic Therapeutic is currently accelerating our oncology portfolio development and is seeking a (Executive/Senior) Medical Director to provide oncology clinical development and/or translational expertise. Reporting directly to the SVP, Clinical Development, the (Executive/Senior) medical director will be responsible for leading the development and execution of the clinical trials in our oncology programs. The successful candidate will work closely with the team members & functions across the organization including our Discovery, Clinical and Regulatory groups as the company’s Oncology program is currently focused on research and early clinical development. This individual will partner with the SVP, Clinical Development to lead external meetings including academic study investigators, advisory meetings with opinion leaders, and interactions with Health Authorities as needed. 

Essential Job Functions: 

• Initiating, communicating, and executing well-conceived clinical development plans in support of Myelofibrosis Development priorities of Morphic 

• Responsible for the strategic and operational medical input to the design, planning, initiation, completion, analysis, and reporting of clinical trials in the oncology/solid tumor therapeutic area 

• Providing clinical input on all IND and preparation activities including data collection, database lock, analysis and write-up of biomarker and pharmacodynamic endpoints 

• Communicating Morphic’s clinical development goals, clinical trial plans and data, as well as clinical program accomplishments to the external community, investigators, key opinion leaders and corporate partners 

• Participating in, and provide clinical support to business development activities on an as-needed basis 

• Perform medical review, assessment, and interpretation of all clinical efficacy/translational/safety data to be reported in clinical study reports to ensure that the data are correct and presented with the appropriate medical interpretation. 

• Work closely with the SVP Clinical Development and other executive team members on broader strategy and development of the clinical development plans for various programs. 

Successful candidates will have the following personal qualities & experiences: 

• A physician scientist who enjoys and has been successful at working closely with discovery/biology teams to analyze and interpret preclinical data, and help to shape our Myelofibrosis indication strategy from a clinical & preclinical point of view 

• Experience in planning and executing clinical trials including FIH (i.e. Dose Escalation/Expansion Cohort studies) in Myelofibrosis, Hem-oncology and solid tumor indications on either the study site or industry side 

• Clinical experience in Hem-oncology (myelofibrosis is a plus) patient care preferred 

• Experience in negotiating clinical trial programs with regulatory authorities a plus 

• Prior experience working in a small, fast-moving, entrepreneurial company a plus 

• Demonstrated ability to collaborate successfully with multiple functions in a team environment 

• Strong written and oral communication skills, including presentation skills 

• Ability to analyze and interpret clinical and efficacy data and develop written reports and presentations of those data.

Cultural Fit 

Our culture is collaborative, one where people enjoy coming to work. We are a small, entrepreneurial company where everyone pitches in and works together to do whatever it takes to get things done. Our team is passionate, enthusiastic, and committed. 

We have a fast-paced, high accountability environment. We have a flat organization, and our leaders lead through influence and interpersonal skills, not command and control. Everyone on the team, including our CEO, is an individual contributor. 

We seek an individual for this position who shares our values and our enthusiasm about bringing new medicines to the patients and families that need them. We seek someone who will enjoy working in a small company environment and be motivated by the opportunity to directly influence and help shape the future direction and culture of our company. 

Professional Qualifications: 


• M.D. or M.D./Ph.D. with experience in driving early clinical development within the adult myelofibrosis/ hem-onco/ solid tumor TA with a strong scientific background is required. 

• A minimum of 3 years (>=5 years preferred) of clinical research experience in Oncology clinical development in university and/or pharmaceutical/ biotech industry is required. 

• Expertise in the areas of drug development, operations, and strategic planning. 

• Experience with preparing clinical sections to support IND submissions 

• Excellent communication skills including experience presenting to a wide variety of audiences such as internal teams, medical and scientific communities. 

• Approximately 25% of domestic and international travel will be required to attend key internal and relevant professional meetings. 


• U.S. (or Foreign Equivalent) Board Certified in Oncology 

• Solid tumor clinical development experience in the context of checkpoint inhibitor programs 

• Deep knowledge of CPI resistance mechanisms 

Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives.  In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.