Senior Scientist, Computational Chemistry

About Morphic Therapeutic

Morphic Therapeutic is a biopharmaceutical company developing a new generation of oral integrin therapies for the treatment of serious chronic diseases, including autoimmune, cardiovascular and metabolic diseases, fibrosis and cancer. In collaboration with Schrödinger, Morphic is advancing its pipeline and discovery activities using its proprietary MInT technology platform which leverages the Company’s unique understanding of integrin structure and biology. For more information, visit is advancing both partnered and fully-owned oral integrin therapeutic candidates with the initial clinical trials beginning in 2020. Our immediate focus is on the areas where the clinical activity of antibody inhibitors of integrins is precedented, thus enabling a rapid path to clinical proof-of-concept. Morphic Therapeutic is located in the AstraZeneca BioHub in Waltham, MA. We are seeking a highly talented and motivated individual to join our culture of teamwork, craftsmanship, tenacity, compassion, integrity, and beauty. 

 Job Description: 

We are seeking an enthusiastic and highly motivated Senior Scientist to join the Computational Chemistry group within Morphic Therapeutic.

Essential Job Functions:

· Design and carry out virtual screens on novel targets of interest

· Deploy state-of-the-art structure-based and ligand-based modeling approaches to drive medicinal chemistry design efforts

· Work with structural biology, medicinal chemistry, DMPK, and data sciences colleagues to interpret results and recommend improvement strategies

· As part of multi-disciplinary design teams, contribute to the success of discovery project team goals ranging from early stage (target ID and hit finding) to late stage (Lead optimization and development candidate identification.)

· Contribute to the development and implementation of the Computational Chemistry strategy at Morphic

· Communicate scientific results effectively internally as well as in external presentations and publications



· Ph.D. in computational chemistry or a related field with 5 years of experience post PhD

· Working knowledge of medicinal chemistry and DMPK principles

· A demonstrated understanding of 3D protein-ligand energetics and their application to molecular design

· Experience with current commercial molecular modeling packages 

· Excellent oral and written communication skills and good presentation skills

· Ability to work in a fast-paced, goal-oriented team environment


· 3+ years of industry experience is preferred 

· Working knowledge of Schrödinger Modelling package (Glide, Desmond, FEP+) is strongly preferred.


Cultural Fit:

Our culture is collaborative, one where people enjoy coming to work. We are a small, entrepreneurial company where everyone pitches in and works together to do whatever it takes to get things done. Our team is passionate, enthusiastic, and committed. 

We have a fast-paced, high accountability environment. We have a flat organization, and our leaders lead through influence and interpersonal skills, not command and control. Everyone on the team, including our CEO, is an individual contributor. 

We seek an individual for this position who shares our values and our enthusiasm about bringing new medicines to the patients and families that need them. We seek someone who will enjoy working in a small company environment and be motivated by the opportunity to directly influence and help shape the future direction and culture of our company. 


 Morphic Therapeutic is an equal opportunity employer committed to providing an environment that maximizes our employees’ development and achievement goals. We strive to treat each employee as an individual, as we seek to foster a spirit of teamwork to help change patients’ lives.  In addition to a competitive compensation and benefits package that includes medical, dental and vision coverage, a 401K and a generous vacation and holiday schedule.