Enliven Therapeutics is a clinical-stage biopharmaceutical company focused on the discovery and development of small molecule inhibitors to help people with cancer not only live longer but live better. The Company aims to address existing and emerging unmet needs with a precision oncology approach that improves survival and enhances overall well-being. Its discovery process combines deep insights in clinically validated biological targets and differentiated chemistry with the goal of designing therapies for unmet needs.

Summary 

Enliven is seeking a highly motivated and experienced Senior Medical Director to support development activities for one or more clinical programs. As a key member of the clinical development team, the Senior Medical Director will work in a highly matrixed environment and collaborate with CMC, Regulatory Affairs, Development Operations, and other teams to advance oncology clinical trials. As part of a fast-paced startup environment, the successful candidate will need to continually re-evaluate and adapt to the changing needs of the company and/or programs. In addition, they need to be able to problem-solve in an agile startup environment. We are seeking an MD board certified in Hematology and/or Oncology with industry experience leading clinical programs across all phases of development.

The role reports to the Vice President, Clinical Development.

Responsibilities:

• Support the design and execution of clinical development plans for Enliven’s oncology programs, ensuring alignment with strategic objectives and timelines
• Provide medical and scientific oversight for clinical trials, including protocol development, study monitoring, data review, and analysis
• Participate in cross-functional project teams with peers from clinical operations, biometrics, clinical pharmacology, biomarker sciences, regulatory affairs, and medical writing
• Establish and maintain relationships with key opinion leaders and clinical investigators in the immunology field and disease areas related to clinical development programs
• Ensure compliance with regulatory requirements and guidelines, while providing leadership for interactions with regulatory agencies
• Collaborate with cross-functional teams, including research, preclinical development, manufacturing, medical affairs, and commercial, to ensure alignment of clinical development plans with overall product development strategy
• Participate in due diligence activities and provide medical expertise in support of  business development initiatives
• Represent Enliven externally at scientific conferences, investor meetings, and other industry events

• MD or equivalent degree, with board certification in oncology/hematology. Preferred clinical experience in small molecule oral delivery for solid and liquid tumors
• Minimum of 5+ years of clinical development experience in the pharmaceutical or biotechnology industry, with a track record of successful drug development
• Strong knowledge of clinical trial design and execution, including experience with adaptive trial designs and biomarker-based approaches
• Deep understanding of regulatory requirements for drug development, including experience leading interactions with global regulatory agencies
• Excellent communication skills, with the ability to effectively communicate complex medical and scientific information to diverse audiences
• Strong interpersonal skills, with the ability to establish and maintain relationships with key opinion leaders, clinical investigators, and internal stakeholders through a highly collaborative approach
• Ability to think strategically and creatively, with a focus on delivering results and driving innovation
• Ability to adapt and problem-solve in an agile, startup environment

The expected salary range for this position is $315,000 - $380,000, prorated for part time work. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance.

Enliven Therapeutics is proud to be an equal opportunity employer. All employment offers are contingent upon the applicant successfully completing a background screen.