We are seeking a hands-on, highly motivated, talented Research Associate to join our R&D team. This individual will focus on ex-vivo or in-vitro cell-based assay development and optimization for drug candidates and screening in support of several ACRDD projects.
The candidate will work as an integral member of a team of chemists, biologists, and proteomic scientists and will formulate chemical biology strategies to integrate into our discovery programs in order to reach hit-to-lead and lead optimization goals.
The candidate should have a proven record of applying sound scientific judgment to answer critical questions, as well as a proven ability to design and implement appropriate experiments. Strong organizational skills and multi-tasking abilities are required. The right candidate should also be very comfortable with working with different types of automated high throughput equipment and imaging equipment. The ability to work independently in a high pace, the multi-disciplinary environment is essential. Direct experience in hematology-oncology, molecular biology, culture of undifferentiated iPSC and in vitro differentiation to neural or other cell types, drug discovery research and/or high-throughput screening, intracellular tracking of peptide drugs, tox profiling, and elucidation of the mechanism of action, targeted protein degradation strongly preferred.
The new hire role would be also to assist with several aspects of NGS analysis interpretation to identify drug targets, mechanisms of resistance, and potential mechanisms of synthetic lethality.
Duties and Responsibilities:
Experience in molecular biology and/or chemical biology is preferred. Prior experience with chromatography and mass spectrometry data analysis, method development, LC and MS instrumentation, and MS Software is a plus. Strong project management skills with the ability to deliver results on schedule in a fast-paced entrepreneurial environment. Capacity to execute tasks independently to achieve goals on an established timeline. Excellent written and oral communication skills, and a personality of risk-taking, positivity, leadership, adaptability, adventurousness, and excitement to work in a dynamic, goal, and performance-oriented team environment. Involved in the planning, execution, and interpretation of experiments (daily). Experimentally support coworkers. Assist in the assembly/writing of manuscripts (scientific papers) and grants (daily). Keep abreast of current literature.
Conduct scientific presentations at national and international meetings (two to three times a
year). Present scientific findings at departmental meetings (monthly).
Perform various administrative tasks (i.e., order supplies, paperwork, etc.)
Bachelor's degree in a science-related field
Microsoft Office Suite, Genespring (data analysis), Statistical software (SPSS, R). Ingenuity Pathway Analysis experience. Cancer/biology-related field of study.