About GondolaBio 

GondolaBio is a clinical-stage biopharmaceutical company focused on developing breakthrough therapeutics for genetic diseases. GondolaBio is an independent sister company to BridgeBio, originally carved out in 2024 after securing $300M in private financing from external investors. GondolaBio aims to leverage cutting-edge biological research to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases. 

Who You Are 

You are a development sciences leader who connects the dots from target engagement to first-in-human and early clinical proof of concept. You think in integrated development plans — pairing nonclinical pharmacology, DMPK, biomarkers, clinical pharmacology, and quantitative sciences into a coherent story that de-risks programs and accelerates decisions. You are hands-on by default, energized by getting into the technical details and driving the work forward in a fast-moving, early-stage environment. You partner naturally across Clinical Development, Regulatory, Research, and CMC, and you bring deep scientific judgment to genetic disease programs — ideally with direct experience advancing oligonucleotide and other novel modalities. Above all, you keep patients at the center of every development decision. 

Key Responsibilities 

Provide scientific strategy and operational leadership across the development sciences functions that take genetic disease programs from candidate selection through first-in-human and early clinical development, including: 

Nonclinical Pharmacology & DMPK Sciences 

• Direct nonclinical PK/PD strategy spanning target engagement, pharmacodynamic response, and efficacy. 

• Oversee in vitro and in vivo ADME and DMPK characterization to support candidate selection and IND-enabling packages. 

Biomarker Sciences & Development 

• Lead biomarker identification and the nonclinical-to-clinical biomarker strategy and execution. 

• Drive clinical biomarker qualifications to support proof of mechanism and proof of concept. 

Clinical Pharmacology & Early Clinical Development 

• Own first-in-human through Phase 2 early clinical sciences and development strategy. 

• Direct clinical pharmacology, including Phase 1 healthy-volunteer and special-population studies. 

Quantitative Sciences 

• Provide leadership across data analytics, pharmacometrics, biostatistics, and data management and data sciences to inform dose selection and program decisions. 

Research Operations 

• Oversee nonclinical and translational study execution and vendor management. 

• Manage clinical pharmacology study execution and associated vendor relationships. 

Bioanalytical Sciences 

• Direct bioanalytical assay development for PK, biomarkers, and immunogenicity. 

• Oversee nonclinical and clinical bioanalytical operations. 

Cross-Functional Leadership 

• Partner closely with Clinical Development, Global Regulatory Affairs, CMC, and Research to deliver integrated development plans and regulatory submissions (pre-IND, IND, FIH, Phase 1/2). 

• Personally drive the technical work across these functions, staying close to the science and the data while leveraging CROs and external partners to deliver, consistent with a lean, hands-on early-stage culture. 

• Represent development sciences to senior leadership, the board, and external advisors, and contribute to portfolio-level prioritization and resourcing decisions. 

 Preferred Education & Experience 

• PhD, PharmD, MD, or equivalent advanced degree in a relevant scientific discipline. 

• Minimum 12+ years of biopharmaceutical drug development experience, including significant time in technical leadership roles. 

• Substantial drug development experience spanning nonclinical through early clinical development, with a track record of advancing programs into and through first-in-human. 

• Demonstrated leadership across two or more of the following: nonclinical pharmacology/DMPK, biomarkers, clinical pharmacology, quantitative sciences, bioanalytical sciences, or research operations. 

• Experience operating in a lean, build-oriented, clinical-stage environment with significant reliance on CROs and external vendors. 

• Thrives in a hands-on, detail-oriented capacity and is energized by driving the work forward directly. 

• Strong record of cross-functional partnership with Clinical Development, Regulatory, and CMC. 

Nice-to-Haves 

• Direct experience with oligonucleotide therapeutics (ASO, siRNA, GalNAc-conjugated) or other novel modalities. 

• Genetic and rare disease development experience. 

• Experience building development sciences infrastructure and teams from an early stage. 

No matter your role at GondolaBio, successful team members are 

• Patient Champions who put patients first, uphold strict ethical standards, and anchor decisions in clinical and scientific integrity. 

• Entrepreneurial Operators who take ownership and drive toward practical solutions, while exercising sound judgment, respecting established processes, and aligning with teammates and leadership. 

• Truth Seekers who are rigorous, detail-oriented, and intellectually honest—comfortable challenging assumptions, engaging with data, and updating their views based on evidence. 

• Collaborative Thinkers who work effectively in data-driven, interdisciplinary environments; listen actively; and welcome questions, debate, and constructive challenge as essential to better decision-making. 

• Individuals Who Inspire Excellence in themselves and those around them. 

• High-quality Executors who deliver against goals and milestones with precision, accountability, and appropriate urgency—without compromising scientific rigor or team alignment. 

What We Offer 

• Patient Days, where we are fortunate to hear directly from individuals living with the conditions we are seeking to impact throughout the year and learn how we can improve our efforts. 

• A culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speak. 

• An unyielding commitment to always putting patients first. 

• A decentralized model that enables our program teams to focus on advancing science and helping patients. Our affiliate structure is designed to eliminate bureaucracy and put decision-making power in the hands of those closest to the science. 

• A place where you own the vision – both for your program and your own career path. 

• A collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our game. 

• Access to learning and development resources to help you get in the best professional shape of your life. 

• Robust and market-competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs). 

• Flexible PTO. 

• Rapid career advancement for strong performers. 

• Potential ability to work on multiple GondolaBio Pharma programs across multiple therapeutic areas over time. 

• Commitment to Diversity, Equity & Inclusion. 

Compensation 

The base pay range for this position is $310,000 to $360,000 per year. The actual compensation offered will be determined based on a number of job-related factors, including experience, skills, qualifications, and location. A bonus plan and equity will also be offered. 

Equal Employment Opportunity 

GondolaBio ServiceCo is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status. Employees of BridgeBio and all affiliated companies should work through their managers to inquire about and learn more about this role.