Senior/Principal Scientist, Nanoparticle Formulations
San Diego, CA Preclinical

Your Impact

Our Gene Therapy Program aspires to develop single treatment disease cures utilizing Poseida’s best-in-class gene editing tools including piggyBac® and cas-CLOVER™. As an integral participant in this effort, you will utilize your skills as a formulation scientist in collaboration with a multidisciplinary team of innovative, enthusiastic, and highly self-motivated scientists to discover non-viral nanotechnologies that safely and efficiently deliver nucleic acids to target cells in afflicted patients. Your participation will have a direct impact on Poseida’s efforts to cure challenging diseases, including cancer, by expanding the reach of our platform technologies.

Job Summary

Poseida Therapeutics, is searching for an outstanding Senior/Principal Scientist to join our Nanotechnology group in San Diego, CA. This position offers an exciting opportunity to develop non-viral nucleic acid delivery tools for genome editing and gene therapy applications. This person will assist in providing day-to-day leadership of discovery and translational activities directed at the formulation of novel nucleic acid delivery systems and will work collaboratively with internal molecular biology, pharmacology, synthetic chemistry, and process development teams.


These include but are not limited to:

  • Lead lipid nanoparticle (LNP) formulation discovery campaigns directed towards achieving safe and efficacious in vivo delivery of Poseida Therapeutic’s proprietary gene insertion/editing systems
  • Work collaboratively with synthetic chemistry, platform, pharmacology, and molecular biology teams to establish feasibility for various novel gene therapy concepts
  • Lead DoE-based screening campaigns directed toward discovering novel LNP compositions that mediate efficient gene insertion and/or gene editing to desired cell types in vivo
  • Critically review and analyze data, and communicate results and conclusions; present and defend ideas in cross-functional meetings
  • Author study design protocols, technical reports, technology transfer documentation, and contribute to regulatory filings
  • Efficiently advance LNPs from discovery to disease related proof-of-concept testing
  • Supervise and mentor 1-3 junior Scientists and/or Research Technicians/Assistants
  • Serve as Formulation Lead within a designated Project or Product Team

Requirements, Knowledge, Skills and Abilities:

  • Ph.D. in Chemical Engineering, Biomedical Engineering, Chemistry, Pharmaceutical Sciences, or related discipline with 6-plus years of relevant, post-graduate, lipid nanoparticle (LNP) formulation experience
  • A minimum of 4-years’ experience in generating LNPs in a preclinical industry setting using state-of-the-art manufacturing methods like advanced microfluidics, T-mixing, and tangential flow filtration (TFF) is a must
  • Strong experience in preparing and characterizing LNPs for in vivo applications as demonstrated through publication record, patent filings, and/or work in a relevant drug development setting is required
  • Familiarity with approaches used to target LNPs to different tissues/cell types in vivo is preferred
  • Experience using design of experiment (DoE) and relevant statistical software packages (JMP) for formulation discovery is preferred and may be considered in lieu of extensive, practical nucleic acid formulation experience
  • Hands-on expertise in basic analytical and biophysical methods used for the characterization of nanoparticle formulations, particularly size, morphology, zeta potential, and nucleic acid encapsulation/release (i.e., DLS, fluorescent assays, HPLC/UPLC, etc)
  • Familiarity with in vivo pharmacology and ADMET concepts as they relate to nucleic acid nanoparticle drugs
  • Experience using predictive data analysis, computational methods/software, and machine learning for formulation and/or drug discovery is a plus but not required
  • Established track record of supervising/mentoring junior researchers
  • Must be self-motivated and experienced in optimizing and advancing LNP formulations within a multidisciplinary team environment with scientists and external collaborators

Salary Range for Senior Scientist: $122,850 to $179,025

Salary Range for Principal Scientist: $148,500 to $187,000

The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type, and length of experience with the industry, education, geographic location, etc.  

Who We Are and What We Do

Based in San Diego, Poseida Therapeutics is a clinical-stage biopharmaceutical company utilizing our unique and proprietary genetic engineering platform technologies to create next-generation cell and gene therapies with the capacity to cure.  We are passionate about making an impact on patients’ lives with the development of our CAR-T therapies in various cancers and gene therapies for rare diseases. Our goal is to deliver potential single treatment cures for patients in need.  Our portfolio of product candidates is specifically designed to overcome the limitations of current generation cell and gene therapeutics.

At Poseida we put people first. Our team is passionate about improving patients’ lives through innovation. See what our team has to say about our culture:

“My favorite part about Poseida is all the people that I get to work with.  Everyone is so passionate about what we’re doing here and there’s so much camaraderie.   It feels like one big enthusiastic family.”

“My favorite part about working at Poseida is the amazing culture and working environment.  Everybody is friendly, professional, collaborative, and has a remarkable can-do and positive attitude.”

As we advance our compelling pipeline, there are endless opportunities for impact and growth.  We encourage you to apply today!