Staff Scientist I – Molecular Neuroanatomy
Description

  

A little about us:


The Lieber Institute for Brain Development (LIBD) was established in 2010 to plot a new course in biomedical research that would change the lives of individuals affected with developmental brain disorders. We are one of the only research institutions in the world focused specifically on understanding how genes and the environment influence the way our brains develop that lead to conditions such as schizophrenia, autism, bipolar disorder and related developmental brain disorders. Through our cutting-edge research, answers are emerging and being translated into a robust pipeline of new drugs in development. And, by focusing on genes and their dynamic interplay with the environment, we are getting even closer to the “holy grail” in medical research, the discovery of strategies for primary prevention.


We are a group of dedicated, multidisciplinary and optimistic researchers, working at the cutting edge of science, utilizing state-of-the-art tools to unlock the mystery of the brain and transform the way we approach the development of new treatments, and ultimately cures. LIBD is an independent 501(c)(3) medical research institute located in the Bioscience Park on the campus of the Johns Hopkins School of Medicine and Hospital in Baltimore, MD.


Job Summary: 


We are seeking an enthusiastic and self-motivated staff scientist with significant experience in molecular neurobiology to join our large, interdisciplinary research team at the Lieber Institute for Brain Development. The successful applicant will work in collaboration with a team of wet bench and computational scientists to create cell type/circuit-specific reference profiles and molecular atlases in brain regions important for reward processing with the goal of better understanding addiction and neuropsychiatric disorders. This position is open to bench laboratory scientists seeking a position within a translational research setting with a focus on next generation sequencing projects using 10x Genomics single cell gene expression and Visium spatial transcriptomics technologies in mouse and postmortem human brain tissue. 


Overview of Duties: 


Responsibilities will include experimental design, executing protocols, analyzing data, oversight of laboratory staff, as well as communicating scientific findings through presentations and publications. 

Specific Duties include:

  • Single nucleus RNA-sequencing
  • 10x Genomics Visium spatial transcriptomics 
  • Flow sorting of postmortem human brain nuclei and genetically tagged mouse neurons 
  • Immunohistochemistry, single-molecule FISH, histological staining, confocal microscopy
  • Supervision and training of junior staff in wet lab
  • Logistical organization and management of data acquisition and analysis 
  • Other duties as assigned
Requirements

  

Minimum Requirements


· Master's degree in Neuroscience or a closely related field is required. PhD preferred. 

· A minimum of 5 years bench experience in molecular/cellular biology, flow cytometry, and/or RNA-sequencing library construction preferred.

· Expertise in human neuroanatomy or mouse circuitry is also beneficial for the cross-species approaches under investigation. 


Familiarity with any of the following topics or techniques is a plus:

· Computational experience or familiarity with computing in R, MATLAB, or Python

· Illumina sequencing

· FACS sorting

· Neuroanatomy


Special Knowledge, Skills, and Abilities:


· Excellent organizational and communication skills

· Initiative to learn new methods and perform work efficiently and carefully are essential.


Physical Requirements:


- Remaining in a seated or standing position for extended periods of time;

- Reaching and grasping to manipulate objects with fingers;

- Mobility, including the ability to maneuver around a laboratory setting including the ability to move materials weighing up to 25 pounds;

- Communication skills using the spoken and written word; 

- Having the ability to receive detailed information through oral communication;

- All other physical demands in a standard laboratory environment.


** If accommodations are needed due to pregnancy or a disability, please contact jobs@libd.org 

  

The Lieber Institute has mandated COVID-19 and influenza vaccines, as applicable. All personnel must certify that they have obtained the necessary inoculations and to maintain a copy of that certification, which employees must provide at the Company's request. Exceptions to the COVID-19 and flu vaccine requirements may be provided, on a case-by-case basis, to individuals for either medical contraindications or sincerely held religious beliefs. Requests for a medical or religious exemption must be submitted in writing to jobs@libd.org. Personnel who do not receive the COVID-19 or flu vaccines due to an exemption must wear a mask in shared spaces. Personnel without documentation of vaccination or valid exemption will be considered noncompliant with coronavirus (COVID-19) vaccination requirements. The employee will receive a written warning from their supervisor that they are not in compliance with the coronavirus (COVID-19) vaccination policy and will then have 15 days to comply (either through vaccination or valid exemption).

For additional information, applicants should visit https://covidinfo.jhu.edu/ https://covidinfo.jhu.edu/health-safety/covid-vaccination-information/


EEOC Statement: At the Lieber Institute, we are committed to a work environment of mutual respect where employment decisions are based on merit. As an equal opportunity employer, the Lieber Institute does not discriminate in employment opportunities on the basis of race, color, religion, color, sex, gender identity/expression, sexual orientation, pregnancy, marital status, age, national origin or ancestry, citizenship, disability (physical or mental), genetic information, military service, or other non-merit based factors protected by state or federal law or local ordinance, with regard to any position or employment for which the applicant or employee is qualified.