Staff Scientist I - Imaging Development


A little about us:

The Lieber Institute for Brain Development (LIBD) was established in 2010 to plot a new course in biomedical research that would change the lives of individuals affected with developmental brain disorders. We are one of the only research institutions in the world focused specifically on understanding how genes and the environment influence the way our brains develop that lead to conditions such as schizophrenia, autism, bipolar disorder and related developmental brain disorders. Through our cutting-edge research, answers are emerging and being translated into a robust pipeline of new drugs in development. And, by focusing on genes and their dynamic interplay with the environment, we are getting even closer to the “holy grail” in medical research, the discovery of strategies for primary prevention.

We are a group of dedicated, multidisciplinary and optimistic researchers, working at the cutting edge of science, utilizing state-of-the-art tools to unlock the mystery of the brain and transform the way we approach the development of new treatments, and ultimately cures. LIBD is an independent 501(c)(3) medical research institute located in the Bioscience Park on the campus of the Johns Hopkins School of Medicine and Hospital in Baltimore, MD.

Job Summary: 

We are seeking an enthusiastic and self-motivated individual with significant experience in microscopy and neurobiology to join our interdisciplinary research group at the Lieber Institute for Brain Development. The successful applicant will work with the Imaging Development group at the Institute and contribute to the management of day-to-day operations in the Institute’s microscopy core, including training new users and assisting current users with ongoing experiments. This position will require interfacing with and providing technical expertise to microscopy core users with varying experience levels and experimental imaging needs. Additionally, the applicant will design and conduct experiments within the Imaging Development team, taking a cross-sectional approach to investigating biological questions of neural development by integrating multi-modal transcriptomics data between iPS-derived neuronal cultures and post-mortem human brain tissue. The successful applicant will thoughtfully design and conduct experiments and analyze data, and will be expected to contribute to training and oversight of junior team members. Attention to detail and the ability to perform work carefully and efficiently is essential. 

Overview of Duties: 

Responsibilities will include experimental design, executing protocols, analyzing data, oversight of laboratory staff, as well as communicating scientific findings through presentations and publications. 

Specific Duties include:

  • Provide core support to Institute scientists performing microscopy-based experiments
  • Staff supervision and training, including development of SOPs for new and existing equipment
  • Development of novel microscopy-based assays
  • Immunohistochemistry and single-molecule fluorescent in situ hybridization 
  • Confocal microscopy 
  • High-Content Imaging acquisition and analysis
  • RNA-seq library construction
  • Programming and data analysis in MATLAB and R programming languages

Minimum Requirements

  • Master’s degree in Neuroscience, Biology, or a closely related field is required, PhD is preferred. 
  • Minimum five years of relevant laboratory research experience, including extensive experience with advanced microscopy techniques, is required. 

Special Knowledge, Skills and Abilities

  • Excellent organizational and communication skills are required
  • Familiarity with any of the following techniques is a plus:
    • Molecular biology and/or Next-generation sequencing
    • iPS cell and neuronal cell culture techniques
    • High-content imaging acquisition and/or analysis
    • Biosensor imaging acquisition and/or analysis
    • Programming in MATLAB or R 

Physical Requirements:

· Remaining in a seated or standing position for extended periods of time;

· Reaching and grasping to manipulate objects with fingers;

· Mobility, including the ability to maneuver around a laboratory setting including the ability to move materials weighing up to 25 pounds;

· Communication skills using the spoken and written word; 

· Having the ability to receive detailed information through oral communication;

· All other physical demands in a standard laboratory environment.

** If accommodations are needed due to pregnancy or a disability, please contact 

EEOC Statement: At the Lieber Institute, we are committed to a work environment of mutual respect where employment decisions are based on merit. As an equal opportunity employer, the Lieber Institute does not discriminate in employment opportunities on the basis of race, color, religion, color, sex, gender identity/expression, sexual orientation, pregnancy, marital status, age, national origin or ancestry, citizenship, disability (physical or mental), genetic information, military service, or other non-merit based factors protected by state or federal law or local ordinance, with regard to any position or employment for which the applicant or employee is qualified.