Research Associate - Molecular Neuroanatomy
Description

  

A little about us:

The Lieber Institute for Brain Development (LIBD) was established in 2010 to plot a new course in biomedical research that would change the lives of individuals affected with developmental brain disorders. We are one of the only research institutions in the world focused specifically on understanding how genes and the environment influence the way our brains develop that lead to conditions such as schizophrenia, autism, bipolar disorder and related developmental brain disorders. Through our cutting-edge research, answers are emerging and being translated into a robust pipeline of new drugs in development. And, by focusing on genes and their dynamic interplay with the environment, we are getting even closer to the “holy grail” in medical research, the discovery of strategies for primary prevention.


We are a group of dedicated, multidisciplinary and optimistic researchers, working at the cutting edge of science, utilizing state-of-the-art tools to unlock the mystery of the brain and transform the way we approach the development of new treatments, and ultimately cures. LIBD is an independent 501(c)(3) medical research institute located in the Bioscience Park on the campus of the Johns Hopkins School of Medicine and Hospital in Baltimore, MD.


Job Summary: 

The Molecular Neuroanatomy group, headed by Dr. Kristen Maynard, has a Research Associate position available immediately. The Research Associate will work on single cell and spatial transcriptomics projects in close collaboration with the R/Bioconductor-powered Team Data Science group, headed by Dr. Leonardo Collado-Torres.  This position is open to neuroscientists with wet bench and dry bench experience seeking a position within a translational research setting with a focus on next generation sequencing projects using 10x Genomics single cell RNA-sequencing and Visium technology in postmortem human brain tissue. The Research Associate will work in collaboration with other team members to execute planned transcriptomic projects that aim to create single cell maps of gene expression in human brain and examine associations with neuropsychiatric disease. We are looking for someone who can contribute to our team environment and who is motivated to apply new technologies and methods to human brain. 


Overview of Duties:

· Generation of single cell and spatial transcriptomic data in postmortem human brain tissue using 10x Genomics technologies. 

· Perform rigorous, and reproducible analyses on RNA-seq datasets from technologies such as bulk RNA-seq, single cell/nuclei RNA-seq and spatial transcriptomics.

· Utilize publicly available data to enrich our findings from the LIBD datasets.

· Communicate with individuals with different expertise such as biologists, computational scientists, and biostatisticians. 

· Present research results at team meetings, LIBD meetings, and scientific conferences as well as contribute to peer-reviewed publications and grant applications.

· Participate in continuous learning activities such as the LIBD rstats club and bootcamps.

· Contribut to manuscript preparation

· Other duties as assigned.  


Requirements

  

Minimum Qualifications:

· Bachelor’s degree in neuroscience, molecular or cellular biology, computational biology, or a related field.

· A minimum of three years related experience is required.


Special Knowledge, Skills and Abilities:


Required

· Basic wet bench skills including molecular biology, tissue cryosectioning, fluorescence microscopy

· Experience with genomic data analysis using R/Bioconductor packages for one or more projects

· Understanding of statistical methods such as linear regression, interaction models, ANOVA, t-Student and F distributions, p-values and false discovery rate (FDR)

· Evidence of computational skills and code version control through GitHub or similar options

· Strong organizational skills, attention to detail, excellent problem-solving skills, excellent written and verbal communication skills

· Ability to balance self-study with asking for help

· Initiative to learn new methods and perform work efficiently and carefully are essential. 


Preferred

· Demonstrated leadership skills and participation in team-oriented activities

· Experience executing experimental protocols and performing computational analysis most commonly exemplified with peer-reviewed publications or pre-prints as well as public GitHub repositories


Physical Requirements:

· Incumbent is required to work in an office environment. 

· Must be able to move about the office and campus as well as remain stationary for extended periods of time.

· Ability to continuously operate a personal computer for extended periods of time.

· Visual acuity as well as mental acuity sufficient to collect and interpret data, evaluate, reason, define problems, establish facts, draw valid conclusions, make valid judgments and decisions are required

· Ability to speak and hear well enough to communicate clearly and understandably with sufficient volume to ensure an accurate exchange of information in normal conversational distance, over the telephone, and in a group setting

· Physical dexterity sufficient to use hands, arms, and shoulders repetitively to operate a keyboard and other office equipment, use a telephone, access file cabinets and other items stored at various levels, including overhead

· Ability to lift or move objects up to 25 lbs.


** If accommodations are needed due to pregnancy or a disability, please contact jobs@libd.org 


The Lieber Institute has mandated COVID-19 and influenza vaccines, as applicable. All personnel must certify that they have obtained the necessary inoculations and to maintain a copy of that certification, which employees must provide at the Company's request. Exceptions to the COVID-19 and flu vaccine requirements may be provided, on a case-by-case basis, to individuals for either medical contraindications or sincerely held religious beliefs. Requests for a medical or religious exemption must be submitted in writing to jobs@libd.org. Personnel who do not receive the COVID-19 or flu vaccines due to an exemption must wear a mask in shared spaces. Personnel without documentation of vaccination or valid exemption will be considered noncompliant with coronavirus (COVID-19) vaccination requirements. The employee will receive a written warning from their supervisor that they are not in compliance with the coronavirus (COVID-19) vaccination policy and will then have 15 days to comply (either through vaccination or valid exemption).


For additional information, applicants should visit https://covidinfo.jhu.edu/ https://covidinfo.jhu.edu/health-safety/covid-vaccination-information/


EEOC Statement: At the Lieber Institute, we are committed to a work environment of mutual respect where employment decisions are based on merit. As an equal opportunity employer, the Lieber Institute does not discriminate in employment opportunities on the basis of race, color, religion, color, sex, gender identity/expression, sexual orientation, pregnancy, marital status, age, national origin or ancestry, citizenship, disability (physical or mental), genetic information, military service, or other non-merit based factors protected by state or federal law or local ordinance, with regard to any position or employment for which the applicant or employee is qualified.