Bioanalytical Scientist
Cambridge, MA
Job Type
Full-time
Description

Marengo Therapeutics is seeking a Bioanalytical Scientist to join us in this exciting phase as we move into the next chapter of bringing our science to cancer patients


Job Summary


We are seeking an enthusiastic, self-motivated individual to join our Development Team as Scientist I/II. The position will report to the Preclinical Lead and the individual will contribute significantly to a small, rapidly expanding company offering opportunities to advance while improving the lives of patients. 


The ideal candidate will be a key member of a growing bioanalytical and pharmacology group, lending support to preclinical and clinical development teams providing bespoke assay and drug metabolism/distribution and pharmacokinetics (DMPK) support from early lead optimization through to Phase 1 trials in patients. Initially, this role will focus on supporting projects advancing molecules from early lead optimization stages through to therapeutic candidate nomination by supporting PK, PD, immunogenicity, and exploratory toxicological assessments in relevant animal models. The successful candidate will lead the development of novel assays to support early understanding of quantitative pharmacology in preclinical species to support advancing our novel lead molecules. This will include designing assays from scratch and considering and evaluating optimal platforms, validating assays according to good scientific practice, and running samples from studies. The successful candidate will also be capable of analyzing pharmacokinetic data and providing basic interpretation, with the opportunity to significantly develop these skills with other pharmacometrics experts and consultants. 


 

Responsibilities and Duties

  • Lead the development and validation of novel assays to measure the disposition and pharmacokinetics (PK) of multi-specific therapeutics in preclinical species, using various biological samples from mostly non-clinical studies. 
  • Responsible for developing high-quality assays to support the assessment of pharmacodynamics and immunogenicity of novel multi-specific therapeutics.
  • Analyze and interpret various types of bioanalytical data, and author and/or review assay and in vivo study protocols and reports
  • Additional responsibilities will include assay troubleshooting, development of new technology platforms, and assay automation
  • Managing technology transfer of immunogenicity and PK methods and related bioanalytical activities to CROs
  • Opportunity to contribute to early PK modeling and human PK/PD simulation with other functions and external consultants
Requirements

Qualifications and Skills

  • Ph.D. in Life Sciences, or a related scientific discipline, with 2-4 years industry experience, or a Master’s degree with 3-5 years industry experience. 
  • Strong technical expertise and direct experience in a variety of bioanalytical methods (ELISA, ECLIA, RIA) using different immunological and biochemical platforms, such as MSD, Gyros, Singulex, or other platforms, and familiarity with any automation platforms are preferred.
  • The candidate must be able to work with human and animal blood, serum and plasma specimens. 
  • A background in pharmacology or drug metabolism or prior industry experience is preferred, preferably in an immunoassay development or DMPK setting. 
  • Experience with basic analysis, manipulation, and interpretation of drug pharmacokinetic data in preclinical studies (particularly with biopharmaceuticals) is also desirable.
  • Excellent record keeping, communication skills, and a customer-oriented mindset.
  • Working knowledge of, or experience with, electronic laboratory notebooks and electronic inventory software 
  • Candidates should demonstrate the ability to multi-task the ability to work under tight timelines with a sense of urgency in a dynamic multi-disciplinary team environment

Marengo is committed to treating all applicants fairly without discrimination. We welcome applications from all individuals, regardless of race, national origin, gender, age, physical characteristics, social origin, disability, union membership, religion, family status, pregnancy, sexual orientation, gender identity, gender expression or any unlawful criterion under applicable law.