Associate Scientist / Scientist, Antibody production and analytics
Job Type

Job Summary

Marengo is seeking an exceptional Scientist to join our Antibody Discovery and Protein Sciences (ADPS) team. The new team member will contribute significantly to a small, rapidly expanding company offering opportunity to advance while improving the lives of patients. 

We are seeking an experienced, versatile and self-driven individual to our growing team of energetic scientists. This is a unique opportunity to collaborate with colleagues in Discovery and Early Development teams to directly contribute to discovering novel IO therapeutics. This individual will play a key role in the design and optimization of our next-generation biologic therapeutics, with a focus on fusion proteins and antibodies. The successful candidate will have a demonstrated in-depth understanding of advanced antibody analytics as applied to assessment of developability of Antibody-derived multi-specific therapeutics and excel in a fast-paced environment.  The candidate will be responsible for advanced lab activities and is expected to make an impact at the organizational level in a matrix team environment.


Responsibilities and Duties  

· Carry out hands-on lab work to express, purify and characterize novel protein therapeutics to support antibody screening and lead optimization in discovery programs

· Develop protocols to generate stable cell lines

· Demonstrate thorough understanding of advanced protein analytical assays. Apply a broad range of protein analytics to assess and optimize the developability features of multi-specific therapeutics. 

· Act as a Subject Matter Expert in Antibody production and analytics and provide guidance to the research project teams

· Analyze and present data, both in written reports and oral presentations

· Effectively manage projects and resources to maximize progress

· Manage collaborations with external CROs

· Exhibit versatility to take on new responsibilities within ADPS group

· Maintain detailed lab notebooks



Qualifications and Skills

· M.S. or PhD in Biochemistry, Molecular or Structural Biology or a closely related field and extensive experience in antibody generation and bioanalytical characterization is required

· Prior experience in pharma or biotech is highly preferred

· Experience in advanced protein analytics including but not limited to stability assessment (DSC, DSF), mass spec, HPLC (SEC, HIC), capillary gel electrophoresis (CE-SDS, cIEF)

· Demonstrated knowledge in developability assessments of antibody therapeutics

· Experience in production of complex Antibody-derived biologics using mammalian host systems and purification using a wide range of AKTA systems

· Experience working in a matrix environment

· Attention to detail and a creative approach mentality to problem solving

· Highly analytical mind, attention to detail, and organizational skills are critical

· Self-motivated with a strong sense of responsibility, integrity, and a collaborative spirit 

· Ability to work independently to design and troubleshoot experiments

· Versatile and quick learner to take on new responsibilities and implement new technologies