Job type: A Full-Time Postdoctoral Scientist or Research Associate to study metabolite-protein interactions
Scientific Roles: Our multidisciplinary laboratory integrates the knowledge and technology of immunology, chemical biology, molecular microbiology, bioinformatic analyses of gene, lipid, and metabolite profiles, and animal studies to discover metabolite and lipid compounds for unconventional T cell activation to fight infections and cancers. Our current projects focus on (i) identifying Mycobacterium tuberculosis metabolites to activate T cells, (ii) determining T cell clones that elicit protective responses against tuberculosis, (iii) characterizing differential metabolite antigen presentation pathways in bacterial infections, and (iv) identifying mammalian and microbial metabolites as T cell antigens or protein ligands to regulate immunity in infections, cancers, and inflammations.
Laboratory and intellectual duties or activities:
o Generate and modify hypotheses based on literature and experimental results.
o Carefully design and pursue experiments to test hypotheses and troubleshoot the assays if failed.
o Summarized rationale, hypotheses, experimental design, results, conclusions, and future studies to present them to lab members and colleagues.
o Write abstracts, prepare posters/talks, and write manuscripts for conference presentations and journal publications.
o Maintain accurate and complete experimental record.
o Development of grant writing skills is encouraged. Preparing or assisting in preparing grant and contract applications may be required.
o Participate in seminars and scientific meetings appropriate to the fields of interest.
o Collaborate with other lab members and colleagues.
o Other relevant duties to complete research projects
Our Ideal Candidates:
o A Postdoctoral Scientist with a doctoral degree or a Research Associate with a master's degree in biochemistry, chemical biology, chemistry, immunology, microbiology, or relevant fields
o Responsible for performing gene cloning, protein expression, and metabolite extraction for metabolomic profiling, structural identification, and functional characterization.
o Open to learning and exploring new areas of science, particularly chemical biology and/or immunology assays for bioactive compound identifications.
o Highly motivated individuals who are self-desired to make major contributions to science.
o Be willing to work collaboratively with lab members and colleagues.
o Equipped with appropriate knowledge and skills.
How to Apply:
In addition to applying here on our career page, please send the following documents to Shouxiong Huang (shuang@txbiomed.org)
(1) Resume or CV
(2) A cover letter
Who We Are:
Texas Biomedical Research Institute is one of the world's leading independent biomedical research institutions dedicated to advancing global human health through innovative biomedical research. Texas Biomed aims to unravel the mysteries of infectious diseases through innovative thinking, creative problem solving and cutting-edge technologies. The Southwest National Primate Research Center (SNPRC) provides broad services in primate research. We are one of seven National Primate Research Centers (NPRCs) with specialized technologies, capabilities, and primate resources, many of which are unique to the SNPRC. Texas Biomed aims to unravel the mysteries of infectious diseases through innovative thinking, creative problem-solving, and cutting-edge technologies, including a state-of-the-art mass spectrometer to be set up.
What We Can Offer You:
• Competitive pay
• 7% Employer-Funded retirement contribution starting day one
• Full insurance benefits
• Holidays, paid time off (PTO), and a paid week off (the last week of December)
• We are proud of our commitment to Diversity, Equity, Inclusion and Belonging!
Texas Biomedical Research Institute provides equal employment opportunities for all qualified employees and applicants without regard to race, color, sex, sexual orientation, gender identity, religion, national origin, disability, veteran status, age, marital status, pregnancy, genetic information, or other legally protected status.