About GondolaBio

GondolaBio is a collection of biopharmaceutical companies focused on developing next-generation therapeutics for genetic diseases. Originally carved out of BridgeBio, GondolaBio secured $300M in private financing from external investors in 2024 and became an independent company within the BridgeBio ecosystem. GondolaBio aims to leverage cutting-edge biological research to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases.

Portal Therapeutics is an early clinical stage biotechnology company, and the lead program in GondolaBio’s portfolio. Portal is developing a novel potential best-in-class therapy for erythropoietic protoporphyria, a severe genetic disease of the blood which results in extreme sensitivity to sunlight and liver damage.

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Who You Are

We seek an experienced entrepreneurial scientist to drive the biology and translational research for Portal Therapeutics. You will lead scientific strategy and direction, assay development, mouse model experimentation, preclinical dose guidance, regulatory document writing, and other translational biology and pharmacology experiments through a combination of internal and external efforts. This job requires excellent communication and interpersonal skills as well as technical and scientific abilities.

Responsibilities

• Lead the biology, pharmacology, and translational research for Portal
• Develop a deep understanding of the biology and pharmacology of the relevant disease area and treatment approaches, and be able to communicate these concepts internally and externally
• Responsible for generating a comprehensive biology and pharmacology package to support US and international regulatory filings
• This individual will be responsible for the design, execution, and interpretation of preclinical studies to address mechanism of action and translational pharmacology studies (in vitro and in vivo)
• Manage relationships with CROs for efficient execution of all the preclinical and translational studies
• Collaborate with cross-functional teams, including DMPK, toxicology, clinical development and regulatory to advance our therapeutic candidates from preclinical stages through clinical development in a fast-paced, dynamic environment
• Develop scientific publications, abstracts, and posters, and investor and layperson-facing materials on the Portal program
• Evaluate expansion indications or additional therapy opportunities
• Represent the program scientifically to internal and external audiences, including investors and the Board of Directors
• Manage research associates or scientists as needed
• Contribute to the drafting of translation- and pharmacology-related sections of regulatory documents including Investigator’s Brochure, clinical protocols, and briefing books
• Contribute to due diligence and gap analysis on potential new GondolaBio assets

No matter your role at GondolaBio, successful team members are:

• Patient Champions, who put patients first and uphold strict ethical standards
• Entrepreneurial Operators, who drive toward practical solutions and have an ownership mindset
• Truth Seekers, who are detailed, rational, and humble problem solvers
• Individuals Who Inspire Excellence in themselves and those around them
• High-quality executors, who execute against goals and milestones with quality, precision, and speed

Education, Experience & Skills Requirements

• Ph.D., MD,or Ph.D./MD degree and expertise in a relevant scientific field with 8+ years of related work experience in pharma or biotech environment 
• Strong scientific background and achievements in bioscience and translational, ideally demonstrated by scientific publications, presentations, and/or patents 
• Proven track record of successfully leading research programs and teams 
• Strong understanding of drug discovery and development processes 
• Excellent communication, leadership, and organizational skills 
• Ability to think strategically and execute effectively 
• Experience in collaborating with cross-functional teams and external partners 
• Knowledge of regulatory requirements and industry standards 
• Demonstrate creative 'out of the box' thinking to solve complex technical problems and champion innovative technologies to achieve project goals 
• Commitment, drive, and ownership mindset 

What We Offer

• Patient Days, where we are fortunate to hear directly from individuals living with the conditions we are seeking to impact throughout the year and learn how we can improve our efforts
• A culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speak
• An unyielding commitment to always putting patients first. Learn more about how we do this here
• A de-centralized model that enables our program teams to focus on advancing science and helping patients. Our affiliate structure is designed to eliminate bureaucracy and put decision-making power in the hands of those closest to the science
• A place where you own the vision – both for your program and your own career path
• A collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our game
• Access to learning and development resources to help you get in the best professional shape of your life
• Robust and market-competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs)
• Flexible PTO
• Rapid career advancement for strong performers
• Potential opportunity ability to work on multiple programs across multiple therapeutic areas over time 
• Partnerships with leading institutions
• Commitment to Diversity, Equity & Inclusion

Compensation: $313,000 - $355,000