Senior/Principal Scientist, RNA Biochemistry
Waltham, MA RNA Biochemistry
Job Type

Do you have the passion to join a group whose mission is to pioneer the discovery of a new class of medicines to treat diseases unaddressed by today’s medicines? Does it excite you to be part of a company with a focus on cancer and genetically validated targets in other disease areas with unmet medical need? If yes, you may be a great fit to join Arrakis on our path to bring powerful new therapies to millions of patients.

Your Impact at Arrakis

The mission of Arrakis Therapeutics is to extend small molecule medicines into new realms of biology by discovering and developing compounds that selectively target RNA (“rSM”). By targeting distinct RNA structure/function relationships, Arrakis is generating drug candidates with novel mechanisms of action for molecular targets that are challenging to drug in disease areas with high unmet medical need.

It is critical to Arrakis’ mission to identify ligandable structures in our mRNA and pre-mRNA targets. To this end, we have built world-class chemical probing methods coupled with next-generation sequencing (NGS) technologies for characterizing RNA structures in living cells and in vitro. We are seeking an experienced scientist to lead a team applying these methods to new targets and developing additional methods that will enhance our structure characterization capabilities.

Job Responsibilities

  • Lead a team responsible for using chemical probing methods to characterize RNA structures in cells and in vitro.
  • Collaborate across functions to identify druggable RNA structures for screening, and to develop actionable three-dimensional models of those structures.
  • Provide deep expertise in RNA structure, chemical probing, and next-generation sequencing.
  • Develop sequencing-based methods to characterize RNA structure that improve our ability to identify ligandable structures and build detailed structure models. 

Interested in learning more about Arrakis? Click on the links below!

Dark Matter Blog: Arrakis achieves escape velocity 

Dark Matter Blog: Following our pole star

Arrakis/Roche Alliance Partnership

Arrakis is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive equal consideration for employment without regard to race, color, religion, national origin or ancestry, sex, pregnancy, sexual orientation, gender identity, age, disability, military service, veteran status, genetic information, or any other characteristic protected by law. 

  • Ph.D. in Molecular Biology, Biochemistry, Cellular Biology, Genetics or equivalent, with 4+ years of industry experience.
  • Strong foundational knowledge of RNA biochemistry and structure.
  • Expertise in sequencing-based methods for interrogating RNA structure (e.g., SHAPE-MaP, DMS, and psoralen).
  • Management experience and a demonstrated ability to develop the careers of researchers.
  • Experience with tissue culture in mammalian systems is strongly preferred.
  • Proven track record of scientific innovation, as demonstrated by peer reviewed publications and/or patents.
  • Proactive and efficient to enable high-quality results while fostering a positive work environment.
  • Exhibits passion and excitement over work. Has a can-do attitude without losing objectivity.
  • Adjusts quickly to changing priorities and conditions and copes effectively with complexity and change.