Associate Director, Computational Biology
Waltham, MA Computational Biology
Job Type

Do you have the passion to join a group whose mission is to pioneer the discovery of a new class of medicines to treat diseases unaddressed by today’s therapies? Does it excite you to be a part of a company with a focus on cancer and genetically-validated targets in other disease areas with unmet medical need?  If yes, you may be a great fit to join Arrakis on our path to bring powerful new therapies to millions of patients.

Your Impact at Arrakis

The mission of Arrakis Therapeutics is to extend small molecule medicines into new realms of biology by discovering and developing compounds that selectively target RNA (“rSM”). By targeting distinct RNA structure/function relationships, Arrakis is generating drug candidates with novel mechanisms of action for molecular targets that are challenging to drug in disease areas with high unmet medical need. Identifying functional elements of the transcriptome that can be targeted by rSM’s and establishing mechanism of action requires integrating data across multiple sources. 

This role will lead the computational biology group with the goal of extracting and integrating biological insights from various types of next-generation sequencing (NGS) data. Leveraging your deep knowledge of bioinformatic tools, and expertise with large biological datasets, you will drive innovative science to deliver novel therapeutics to patients. The ideal candidate will enjoy working in a collaborative, fast-paced start-up environment, leveraging a high degree of scientific rigor, creativity and innovation. 

Job Responsibilities

  • Provide both scientific and strategic leadership within the computational biology team and directly manage and mentor scientists in the team
  • Lead projects validating biological hypotheses and subsequently develop resources and technologies leveraging this knowledge to advance and accelerate therapeutic programs
  • Lead efforts to the design of multi-disciplinary strategies for deploying state-of-the-art NGS technologies for addressing business and scientific needs through-out the company
  • Work with Scientists to develop and maintain robust analysis pipelines and analyses of both internal and public datasets
  • Work effectively in a cross-functional capacity with the RNA biology, assay development and medicinal chemistry teams to deliver high-quality results in an efficient manner
  • Effectively communicate scientific proposals, experimental outcomes, and project goals and progress across the organization

Interested in learning more about Arrakis? Click on the links below!

Dark Matter Blog: Arrakis achieves escape velocity 

Dark Matter Blog: Following our pole star

Arrakis/Roche Alliance Partnership

Arrakis is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive equal consideration for employment without regard to race, color, religion, national origin or ancestry, sex, pregnancy, sexual orientation, gender identity, age, disability, military service, veteran status, genetic information, or any other characteristic protected by law.

  • Ph.D. in Bioinformatics, Computational Biology, or related field
  • 7+ years of relevant industry experience required
  • Direct experience managing and mentoring junior scientists
  • Extensive expertise in common programing and scripting languages (python, R, C++, etc.)
  • Demonstrated expertise in analysis of multiple types of NGS data (such as RNA-seq, Ribo-seq, CAGE-seq, SHAPE-MaP, etc.)
  • Experience writing, testing, and maintaining version-controlled software and pipelines using modern workflow management frameworks (Snakemake, Nextflow, Luigi, ect.)
  • Proven track record of scientific innovation, as demonstrated by peer reviewed publications and/or and patents
  • Familiarity with key concepts and computational tools related to RNA structure, alternative splicing, translation, or other areas of RNA biology is a plus
  • Excellent written and verbal communication skills with a demonstrated ability to communicate the big picture concepts
  • Exhibits passion and excitement over work and brings a can-do attitude without losing objectivity
  • Adjusts quickly to changing priorities and conditions and copes effectively with complexity and change