Scientist, Chemistry (Chemical Biology)
Waltham, MA Chemistry
Job Type

Do you have the passion to join a group whose mission is to pioneer the discovery of a new class of medicines to treat diseases unaddressed by today’s therapies? Does it excite you to be a part of a company with a focus on cancer and genetically validated targets in other disease areas with unmet medical need? If yes, you may be a great fit to join Arrakis on our path to bring powerful new therapies to millions of patients.

Your Impact at Arrakis

The mission of Arrakis Therapeutics is to extend small molecule medicines into new realms of biology by discovering and developing compounds that selectively target RNA (“rSM”). By targeting distinct RNA structure/function relationships, Arrakis is generating drug candidates with novel mechanisms of action for molecular targets that are challenging to drug in disease areas with high unmet medical need.

We are seeking a chemical biologist to join our fast-paced multidisciplinary rSM drug discovery team. This key hire will enjoy a collaborative multidisciplinary start-up environment with integrity and innovation being central to our culture and mission. The ideal candidate would have a strong synthetic background to enable the rapid synthesis of chemical biology probes and tool compounds, as well as experience with target identification and target engagement methodologies. This is an opportunity to contribute to a cutting-edge drug discovery platform and fulfill a vital high impact function in our fast-growing company.


  • Routine design and synthesis of chemical biology probes and related compounds, including supervising the synthesis of key intermediates and building blocks at external CROs
  • Design and execution of experiments aimed at identifying the cellular targets of Arrakis’ rSMs, such as photoaffinity labeling, RNA structure probing, affinity-isolation, mass spectrometry, and/or proteomic/sequencing workflows.
  • Work collaboratively with Arrakis’ drug discovery project teams to identify promising rSMs to pursue under the target engagement team; work within the target engagement team to triage experiments to best align with Arrakis’ overall research goals
  • Foster a positive and collaborative work environment across research functions.
  • Contribute to Arrakis’s scientific publications and patent applications
  • PhD in Organic Chemistry or Chemical Biology, with postdoctoral or industry experience preferred
  • Experience designing and executing multistep synthetic routes to deliver small molecules and probes for testing in biological and chemical biological assays
  • Experience designing and executing experiments aimed at identifying biological targets of small molecules using a range of methodologies
  • Experience with basic mammalian cell culture techniques, including routine maintenance of cell lines, lysate preparation, imaging, etc.
  • Flexibility to perform wet lab work in either chemistry or biology to accommodate changes in project priorities and/or scientific direction.
  • Up-to-date knowledge of advances in synthetic chemistry and chemical biology
  • Fluency in working within a multi-disciplinary team to devise experiments that illuminate critical problems

Interested in learning more about Arrakis? Click on the links below!

Dark Matter Blog: Arrakis achieves escape velocity

Dark Matter Blog: Following our pole star

Arrakis/Roche Alliance Partnership

Arrakis is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive equal consideration for employment without regard to race, color, religion, national origin or ancestry, sex, pregnancy, sexual orientation, gender identity, age, disability, military service, veteran status, genetic information, or any other characteristic protected by law.