Associate Scientist/Senior Associate Scientist, RNA Biochemistry
Waltham, MA RNA Biochemistry
Job Type

Do you have the passion to join a group whose mission is to pioneer the discovery of a new class of medicines to treat diseases unaddressed by today’s therapies? Does it excite you to be a part of a company with a focus on cancer and genetically-validated targets in other disease areas with unmet medical need? If yes, you may be a great fit to join Arrakis on our path to bring powerful new therapies to millions of patients.

Your Impact at Arrakis

The mission of Arrakis Therapeutics is to extend small molecule medicines into new realms of biology by discovering and developing compounds that selectively target RNA (“rSM”). By targeting distinct RNA structure/function relationships, Arrakis is generating drug candidates with novel mechanisms of action for molecular targets that are challenging to drug in disease areas with high unmet medical need.

New potential target-rSM pairs must be rapidly assessed and experimentally evaluated to triage potential drug development. We employ a range of techniques from vitro biochemical assays coupled with next-generation sequencing (NGS), to assays in cell culture, all with the goal of compiling data for rSM-RNA binding and molecular mechanism. You will be part of a team of researchers carrying out cutting edge research to forge a new path in therapeutics. Accordingly, we value those who are flexible and adaptable to new challenges and techniques. The ideal candidate will enjoy working in a collaborative, fast-paced start-up environment, leveraging a high degree of integrity, intelligence, and innovation to make a large impact on our mission.

Job Responsibilities

  • Perform large scale, multiplexed experiments including RNA crosslinking and RNA chemical probing (with SHAPE reagents or equivalent).
  • Perform NGS library preparation on in vitro RNA.
  • Culture cell lines for assays
  • Develop novel or adapt existing NGS library preparation methods to enable novel assays of rSM binding.
  • Perform Illumina sequencing on a MiSeq instrument and interface with computational biologists to transfer data and sample information.
  • Generate new and innovative approaches to problems by exhibiting a probing mind and penetrating insights. 
  • Carefully document experiments in an electronic lab notebook and communicate results to collaborators.
  • Work effectively with a cross-functional biology, informatics, assay development and chemistry team to deliver high-quality results in an efficient manner.

Interested in learning more about Arrakis?  Click on the links below!

Dark Matter Blog: Arrakis achieves escape velocity 

Dark Matter Blog: Following our pole star

Arrakis/Roche Alliance Partnership

Arrakis is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive equal consideration for employment without regard to race, color, religion, national origin or ancestry, sex, pregnancy, sexual orientation, gender identity, age, disability, military service, veteran status, genetic information, or any other characteristic protected by law.

  • Master’s degree and 3+ years' of relevant industry experience or Bachelor’s degree and 5+ years’ relevant industry experience
  • Demonstrated ability to establish NGS methods and perform sequencing-based assays.
  • Extensive experience with NGS library preparation.
  • Detailed knowledge of library preparation to allow method adaptation for specific tasks with minimal supervision.
  • Experience in chemistry or chemical biology.
  • Experience with mammalian cell culture.
  • Ability to work both independently with minimal supervision and cooperatively as part of a team. 
  • Proactive and efficient to enable high-quality results while fostering a positive work environment.
  • Exhibits passion and excitement over work. Has a can-do attitude without losing objectivity.
  • Adjusts quickly to changing priorities and conditions and copes effectively with complexity and change.