Scientist/Senior Scientist, Structural Biology
Waltham, MA Structural Biology
Job Type

Do you have the passion to join a group whose mission is to pioneer the discovery of a new class of medicines to treat diseases unaddressed by today’s therapies? Does it excite you to be a part of a company with a platform that can address any disease area with high unmet medical need? If yes, you may be a great fit to join Arrakis on our path to bring powerful new RNA-targeted small molecule (rSM) medicines to millions of patients.  

Your Impact at Arrakis

The mission of Arrakis Therapeutics is to extend small molecule medicines into new realms of biology by discovering and developing compounds that selectively target RNA. By targeting distinct RNA structure:function relationships, Arrakis aims to generate drug candidates with novel mechanisms of action for molecular targets that are challenging to drug with other approaches, opening up vast new realms of human biology for medicine. 

The Structural Biology group is looking for a strong, enthusiastic candidate to join our team and make an immediate impact on high priority targets critical to our mission. It is critical to Arrakis’ mission to determine structural features of our RNA targets and to identify druggable RNA structural motifs. The successful candidate will support all aspects of drug discovery by interrogating RNA structure with biomolecular NMR spectroscopy and other structural approaches. This role will interface with consultants and contractors and collaborate across disciplines within Arrakis. The ideal candidate will enjoy working in a collaborative, fast-paced start-up environment, leveraging a high degree of integrity, intelligence and innovation to make a large impact on our mission.

Job Responsibilities

  • Provide biomolecular NMR expertise in RNA structure characterization and targeted small molecule drug discovery 
  • Design RNA constructs and isotope labeling schemes for structural and biophysical characterization 
  • Develop and implement NMR experiments to probe and characterize the structure, dynamics and interactions of RNA and small molecules ligands 
  • Validate and characterize lead compounds using ligand- and RNA-observed NMR methods
  • Operate and support maintenance of NMR spectrometer
  • Work effectively in a cross-functional capacity with other biophysicists, medicinal chemists, RNA biochemists, and structural biologists to deliver high-quality results and address specific project needs and challenges
  • Maintain scientific and technical expertise through familiarity with scientific literature and attending conferences
  • Contribute to Arrakis’ scientific publications and patent applications
  • Interface with CROs and NMR facilities
  • PhD in Biochemistry, Biophysics, Molecular Biology or related scientific field with 5+ years of experience elucidating the structure of RNA and RNA-small molecules
  • Strong foundational knowledge of NMR spectroscopy (modern 1D, 2D and 3D methods). Basic knowledge of isotope labeling, RNA synthesis and purification
  • Expertise in RNA structural biology and RNA biochemistry
  • Familiarity with biophysical and structural biology methods (e.g., cryo-EM, X-Ray, SAXS, AFM, MS, SPR, etc.)
  • Familiarity with biomolecular structure modeling and RNA-ligand interactions
  • Proven track record of scientific innovation, as demonstrated by peer reviewed publications and/or and patents
  • Proactive and efficient to enable high-quality results while fostering a positive work environment
  • Exhibits passion and excitement over work. Has a can-do attitude without losing objectivity
  • Adjusts quickly to changing priorities and conditions and copes effectively with complexity and change.

Interested in learning more about Arrakis? Click on the links below!

Arrakis/Amgen Partnership (Jan. 2022)

Arrakis/Roche Alliance Partnership (Apr. 2021)

Dark Matter Blog: Arrakis achieves escape velocity 

Dark Matter Blog: Following our pole star 

Arrakis is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive equal consideration for employment without regard to race, color, religion, national origin or ancestry, sex, pregnancy, sexual orientation, gender identity, age, disability, military service, veteran status, genetic information, or any other characteristic protected by law.