About TRIANA Biomedicines 

TRIANA Biomedicines is a Greater Boston biotechnology company building the leading molecular glue discovery platform to regulate disease targets that are difficult to address with any other modality. TRIANA’s drug discovery engine is powered by high-resolution structural insights, state-of-the-art AI and computational tools, and bespoke chemical libraries. 

TRIANA’s target-first and rational approach to molecular glue discovery is currently focused on inducing or enhancing the degradation of high-profile cancer targets. The therapeutic approach pioneered by TRIANA has the potential to fundamentally change the paradigm of small molecule drug discovery and bring significant therapeutic benefits to patients.  TRIANA is a private company with a top-tier investor syndicate. 

We are seeking an experienced immunologist with deep in vitro and in vivo pharmacology expertise to join our Biology and Translational Sciences group. This role is central to advancing discovery programs from hit validation on by establishing clear mechanistic and translational links between target degradation and disease-relevant immunological outcomes in autoimmune and inflammatory disease.

We are looking for a scientifically rigorous, highly accountable individual who thrives in a fast-paced biotech environment and is motivated by generating decisive data that drives program progression.

Responsibilities

• Assay Development: Design, develop and      implement robust disease relevant cell-based assays to assess target      engagement, protein degradation, and downstream pathway      modulation.
• Mechanistic Biology: Design and execute      experiments that connect target degradation to phenotypic response in primary human      immune cells and in validated in vivo models of autoimmune disease.
• In Vivo      Pharmacology: Design, manage and interpret in vivo studies conducted with      external partners in rodent models of autoimmune and inflammatory disease      (e.g., rheumatoid arthritis), including PK/PD and efficacy studies, and      translate target degradation and pharmacodynamic readouts into      disease-relevant endpoints.
• Data Generation      & Interpretation: Identify critical      project questions and produce high-quality, actionable      datasets that guide stage-appropriate program decisions. 
• Collaboration and Communication: Distill      complex biological data into clear insights and communicate findings      effectively to cross-functional partners and leadership; maintain thorough      and accurate experimental documentation.

Qualifications

• Demonstrated track record advancing      discovery-stage immunology and inflammation programs to in vivo proof      of concept in a biotech or pharmaceutical environment.
• Extensive hands-on expertise in molecular and      cellular biology, including cell culture, gene knockout and knockdown approaches (e.g., CRISPR/Cas9, RNAi), transfection and lentiviral systems, cell      signaling and pathway analysis, immunoprecipitation/immunoblotting,      qRT-PCR, and proliferation or viability assays.
• In-depth experience      with rodent models of autoimmune and inflammatory disease (e.g., collagen-      or adjuvant-induced arthritis, humanized or adoptive transfer models),      spanning study design, dosing regimens, and interpretation of disease and      pharmacodynamic readouts, including ex vivo immunophenotyping; comfortable      overseeing CRO-run studies and interpreting clinical scoring and      histopathology data.
• Solid immunology      expertise across innate and adaptive immunity, with hands-on flow      cytometry, primary immune cell isolation and culture, cytokine profiling,      and immune functional assays.
• Clear, effective      communicator who collaborates across scientific disciplines and presents      rigorous analyses that support informed program decisions.
• Familiarity with      targeted protein degradation or molecular glue mechanisms preferred;      experience supporting IND-enabling studies in autoimmunity is a plus.

Education & Experience

Ph.D. in Immunology, Immunobiology, or a related discipline with 6+ years of post-graduate experience (industry experience preferred) or B.S./M.S. with 12+ years of industry experience.

We welcome applications from skilled individuals whose qualifications may not fit the criteria outlined above.

Base Salary Range: $130-$145k

Our Culture

Our Team is our greatest asset at TRIANA. We are proud to work with an integrated group of individuals from an extensive range of backgrounds and experiences. Diversity, Equity, Inclusion and Belonging are important aspects of our culture. We embrace our differences and cultivate an environment that drives better collaboration and innovation by striving to ensure that all coworkers have an ongoing positive experience while being their authentic selves.

Our Values

At TRIANA we are empowered to act. We dare to create transformative medicines for patients. Our creativity and dedication are the glue that unites us in pursuit of our mission. 

Thank you for your interest in TRIANA!