Program Team Leader, Vice President 

About BridgeBio Oncology Therapeutics

BBOT is a clinical-stage biopharmaceutical company advancing a next-generation pipeline of novel small molecule therapeutics targeting RAS and PI3K malignancies. BBOT has the goal of improving outcomes for patients with cancers driven by the two most prevalent oncogenes in human tumors. For more information visit BBOTx.com.

Who You Are

We are seeking a Program Team Leader (PTL), Vice President to serve as the strategic and operational leader for BBOT’s clinical development programs. Reporting to the Chief Medical & Development Officer, the PTL will have high-level accountability for the delivery of business objectives and portfolio value across the full product lifecycle. This is a visionary leadership role for an entrepreneurial scientist-executive who excels at leading cross-functional teams as the program leader, driving ambitious but deliverable product strategies, and building credibility with internal and external stakeholders at the highest levels. The PTL will be instrumental in advancing BBOT’s mission to deliver transformative oncology therapies to patients.

Responsibilities

Strategic Program Leadership 

• Lead the      cross-functional program team (core team and sub-teams) to define, refine,      and execute the integrated global product strategy across the full      development lifecycle—from early-phase through initial approval, launch,      and lifecycle indications
• Serve as      the primary accountable leader for program delivery, ensuring milestones,      timelines, and budget targets are met; proactively identify risks and lead      the team in developing and executing mitigation strategies
• Drive      ambitious and deliverable product strategy by identifying and maximizing      opportunities for the program; coalesce diverse internal and external      stakeholder perspectives to inform key decisions and align the      organization
• Ensure      appropriate governance and compliance across all program activities;      protect BBOT’s rights, data, and intellectual property throughout the      development and commercialization lifecycle
• Represent      the program in interactions with BBOT senior leadership, the Board, and      external stakeholders; provide clear, compelling updates on program      status, strategy, and value creation

Cross-Functional Team Leadership 

• Build,      lead, and inspire high-performing cross-functional program teams spanning      Clinical Development, Clinical Operations, Regulatory Affairs,      Translational Medicine, Clinical Pharmacology, CMC, and other relevant      functions
• Foster a      culture of collaboration, accountability, scientific rigor, and      entrepreneurial problem-solving within the program team; ensure team      members are aligned, motivated, and empowered to deliver
• Lead      integrated program planning across all functions, ensuring clear      ownership, dependencies, and resource alignment for all program-critical      activities
• Serve as      the primary point of escalation and decision-making authority for      cross-functional program issues; facilitate rapid, well-reasoned decisions      to maintain program momentum

Scientific and Clinical Strategy 

• Provide      strategic scientific and clinical leadership for assigned programs,      including input into clinical development plans, protocol design, patient      selection strategies, biomarker integration, and data interpretation
• Translate      emerging clinical and scientific data into strategic insights that shape      program direction; lead data review meetings and ensure findings are      rapidly and accurately communicated to internal and external stakeholders
• Champion      the integration of precision medicine and biomarker strategies into      program development plans, partnering closely with Translational Medicine      and Clinical Pharmacology
• Build      and maintain productive relationships with key external oncology opinion      leaders, academic collaborators, investigators, cooperative groups, and      patient advocacy organizations to strengthen BBOT’s scientific position      and program execution

Regulatory and Commercial Alignment 

• Serve as      the program-level strategic interface with Regulatory Affairs to shape      global regulatory strategy and ensure consistent, proactive engagement      with FDA, EMA, and other global health authorities
• Ensure      program strategies are informed by deep understanding of the competitive      landscape, payer environment, and commercial opportunity; integrate      commercial insights and market research into development planning
• Support      and contribute to regulatory submissions, health authority meetings, and      interactions with investigators and advisory committees as the senior      scientific and strategic program representative

Requirements

Education and Qualifications 

• M.D.,      Pharm.D., Ph.D., or equivalent postgraduate qualification in a relevant      scientific or medical field; M.D. or M.D./Ph.D. strongly preferred
• Minimum      15 years of progressive experience in oncology drug development in the      pharmaceutical or biotechnology industry, with a demonstrated track record      of successfully advancing programs from early-phase clinical development      through regulatory approval
• Proven      experience leading integrated cross-functional program teams in a matrix      environment, with demonstrated ability to align diverse functions and      stakeholders around a common strategic vision
• Deep      expertise across the oncology drug development process, including clinical      development strategy, biomarker and precision medicine integration,      regulatory strategy, and commercial considerations
• Experience      leading both early-stage and late-stage oncology programs, with the      regulatory and commercial experience of successful drug product approval      and launch
• Strong      external credibility with key oncology thought leaders, payers, health      authorities, and the broader oncology scientific community
• Visionary,      entrepreneurial leadership style with exceptional problem-solving      capability, strategic agility, and the drive to succeed in a lean,      fast-paced environment
• Outstanding      communication, influencing, and executive presence; able to represent BBOT      credibly and compellingly at the highest internal and external levels
• Experience      in RAS, PI3K, or related oncogenic signaling pathways is a plus; small      molecule oncology experience preferred
• Prior      experience in a lean, startup, or high-growth biotech environment is      highly desirable