The Company:

Larimar Therapeutics Inc. is a publicly held clinical-stage biotechnology company focused on developing treatments for patients suffering from complex rare diseases using its novel cell penetrating peptide technology platform. Our lead product candidate, Nomlabofusp (CTI-1601), is a subcutaneously administered, recombinant fusion protein intended to deliver human frataxin (FXN), an essential protein to the mitochondria of patients with Friedreich’s ataxia. Friedreich’s ataxia is a rare, progressive, and fatal disease in which patients are unable to produce sufficient FXN due to a genetic abnormality. 

We have assembled an experienced management team, each of whom has over 20 years of pharmaceutical industry experience. Our management team, employees, and consultants have significant expertise in discovery, nonclinical and clinical development, regulatory affairs, manufacturing and CMC. 

Our company’s strategy is to become a leader in the treatment of rare diseases by leveraging our cell-penetrating technology platform and applying our team’s know-how to the development of Nomlabofusp and our pipeline projects. We are best characterized by entrepreneurial and scientific leadership and a participatory workforce committed to success.[FN1] 

Position Overview:

The Senior Director, Commercial Operations will lead the development and execution of the commercial operating infrastructure needed to support the launch and ongoing commercialization of nomlabofusp. Reporting to the VP, Commercial, this leader will translate commercial strategy into scalable systems, practical processes, and actionable insights that enable operational excellence and effective cross-functional execution.

This role will oversee Commercial Operations launch readiness, commercial systems, patient-based forecasting, business intelligence, and field effectiveness. Responsibilities include performance reporting and business reviews, customer segmentation and targeting, territory and deployment planning, and the co-design and administration of sales force incentive compensation programs in partnership with Sales Leadership. The Senior Director will establish policies and governance that support consistent, compliant execution from launch through ongoing commercialization.

In partnership with IT and cross-functional stakeholders, this leader will develop and deploy integrated enterprise platforms that improve operational efficiency and provide reliable, privacy-appropriate access to patient-level and commercial performance data. The role will oversee Commercial Operations vendors, including CRM providers and data aggregators, with accountability for implementation, service delivery, data quality, and budget management. Success requires both strategic leadership and hands-on execution in an entrepreneurial environment.

Key Responsibilities:

Commercial Operations Launch Readiness

• Lead Commercial Operations launch readiness in partnership with the VP, Commercial, translating commercial strategy into an integrated implementation roadmap for systems, data, field processes, and vendor capabilities.
• Establish milestones, readiness criteria, dependencies, and risk mitigation plans; coordinate resolution of operational gaps before launch and through the transition to ongoing commercialization.
• Establish a regular commercial business review cadence with Commercial, Market Access, Patient Services, and Finance, using agreed performance indicators to identify execution gaps, recommend corrective actions, and track decisions and accountable owners.

Forecasting

• Develop and maintain patient-based demand forecasts with Commercial, Market Access, Patient Services, and Finance, incorporating assumptions for diagnosis, treatment eligibility, uptake, time to treatment, and persistence. Conduct scenario and sensitivity analyses, reconcile actual performance against assumptions, and provide demand inputs to Supply Chain.
• Partner with Commercial and Finance teams to develop, analyze, and communicate commercial program budgets, ensuring accurate and timely forecast reporting.
• Lead the development and delivery of daily and weekly product revenue reports in collaboration with Finance.
• Support monthly and quarterly revenue forecasting processes, ensuring alignment with strategic and financial objectives.

Business Intelligence and Analytics

• Collaborate with Commercial stakeholders to design, implement, and maintain technology and analytics solutions that align with the organization’s strategic direction.
• Partner with cross-functional teams to identify and prioritize high-impact insights across key business areas, including Sales, Medical Affairs, Marketing, Finance, Market Access, Patient Services, and IT.
• Develop and validate dynamic dashboards and analytical tools to integrate and interpret diverse data sources, driving actionable business outcomes.
• Establish data governance and reporting standards to ensure accuracy, consistency, and responsiveness for executive-level and field-based information requests.
• Partner with Patient Services and Market Access to define patient journey metrics, including referral-to-treatment conversion, time to treatment, access barriers, and persistence. Integrate authorized hub, specialty pharmacy, distribution, and CRM data, as applicable, to identify operational bottlenecks while maintaining privacy safeguards, role-based access, and appropriate separation of patient information.

Field Operations

• Lead the design, implementation, and management of the company’s customer relationship management (CRM) system in partnership with Commercial, IT, Quality, and Finance teams.
• Partner with Sales and Marketing to lead customer and account segmentation, targeting, field force sizing, deployment, and region and territory alignment. Establish call planning and account coverage processes, evaluate reach and engagement, and recommend adjustments to resource allocation as market needs evolve.
• Co-design and administer incentive compensation programs with Sales Leadership, Finance, HR, and Compliance, including goal-setting methodologies, sales crediting, payout validation, exception handling, and dispute resolution. Evaluate plan effectiveness and recommend refinements aligned with commercial objectives and appropriate field behaviors.
• Oversee day-to-day field operations support, including vehicle programs, data management, reporting, and CRM optimization, ensuring reliable processes and timely resolution of operational issues.
• Manage data inquiry processes and stewardship initiatives to ensure data integrity and support field team effectiveness.

Trade Relations

• Collaborate with Manufacturing, Supply Chain & Quality to ensure seamless integration between manufacturing and distribution operations.
• Partner with Market Access and Finance to support Commercial objectives related to Gross-to-Net calculations, inventory management, chargebacks, and product returns.

Additional Responsibilities

• Partner with IT to define and advance Larimar’s enterprise data strategy.
• Lead selection, implementation, and ongoing performance management of Commercial Operations vendors with IT, Finance, Legal, and Procurement, as applicable. Define statements of work, service-level expectations, budgets, acceptance criteria, and escalation processes; monitor delivery, data quality, and business continuity.
• Perform additional duties and strategic initiatives assigned by the VP, Commercial. 

Qualifications:

Experience

• Minimum of 10 years of experience in the pharmaceutical or biotechnology industry, with a focus on Commercial Operations, Business Intelligence, or Analytics.
• Bachelor’s degree in Business, Data Analytics, or a related field; equivalent relevant experience will be considered.
• Demonstrated expertise in forecasting, data management, and commercial analytics.
• Demonstrated experience building and operationalizing commercial capabilities for a pharmaceutical or biotechnology product launch, including CRM implementation, field planning, commercial data integration, and vendor management. 
• Experience supporting a first commercial launch preferred.
• Strong verbal and written communication skills, with proven organizational, time management, and project management capabilities.
• Experience within the rare disease sector preferred.

Vision and Adaptability

• Proven ability to operate in a startup environment with a ‘self-starter’ mentality.
• Energized by the opportunity and the need to ‘build it ourselves.’
• Driven to get it done for the patients who depend on us.

Benefits:

Larimar Therapeutics offers all employees incentive stock options, a comprehensive benefits plan including 401K, and a flexible PTO policy.

We are committed to equal-employment principles, and we recognize the value of committed employees who feel they are being treated in an equitable and professional manner. We strive to find ways to attract, develop and retain the talent needed to meet business objectives, and to recruit and employ highly qualified individuals representing the diverse communities in which we live.

Employment policies and decisions on employment and promotion are based on merit, qualifications, performance, and business needs. The decisions and criteria governing the relationship with all candidates and employees are made in a non-discriminatory manner—without regard to age, race, color, national origin, gender (including pregnancy, childbirth or medical condition related to pregnancy or childbirth), gender identity or expression, religion, physical or mental disability, medical condition, legally protected genetic information, marital status, veteran status, military status, sexual orientation, or any other factor determined to be an unlawful basis for such decisions by federal, state, or local statutes.