A little about us:
The Lieber Institute for Brain Development (LIBD) was established in 2010 to plot a new course in biomedical research that would change the lives of individuals affected with developmental brain disorders. We are one of the only research institutions in the world focused specifically on understanding how genes and the environment influence the way our brains develop that lead to conditions such as schizophrenia, autism, bipolar disorder and related developmental brain disorders. Through our cutting-edge research, answers are emerging and being translated into a robust pipeline of new drugs in development. And, by focusing on genes and their dynamic interplay with the environment, we are getting even closer to the “holy grail” in medical research, the discovery of strategies for primary prevention.
We are a group of dedicated, multidisciplinary and optimistic researchers, working at the cutting edge of science, utilizing state-of-the-art tools to unlock the mystery of the brain and transform the way we approach the development of new treatments, and ultimately cures. LIBD is an independent 501(c)(3) medical research institute located in the Bioscience Park on the campus of the Johns Hopkins School of Medicine and Hospital in Baltimore, MD.
We are seeking a postdoctoral fellow to join our interdisciplinary research team to develop a project that studies molecular and cellular signaling in attention- and/or reward-related circuits. Our lab uses a cross-species, intersectional approach to study how programs of gene expression in defined populations of cells contribute to circuit function and control of behaviors that are relevant for neuropsychiatric disorders. Specifically, the laboratory uses genetic manipulation and viral transgenesis in combination with molecular, cellular and systems-level techniques in mouse models, and integrate these data with cell- and circuit-specific transcriptomic studies in the postmortem human brain. Postdoctoral fellows will have the opportunity to develop and build an independent research project that capitalizes on the power of these tools and rapidly emerging data in the human brain to study the role of behaviorally-relevant cell populations in the context of brain circuits associated with reward signaling and/or attention.
Available techniques for project:
· Flow sorting of genetically tagged mouse neurons and/or postmortem human brain nuclei for single nucleus RNA-sequencing
· Stereotaxic surgeries for viral labeling, optogenetic/chemogenetic manipulation of defined cell populations, mouse behavior assays
· in vivo electrophysiology (recording LFPs, EEG or ECog) in mouse models
· miniscope imaging in mouse models
· Single nucleus RNA-sequencing
· Spatial transcriptomics
· Immunohistochemistry, single-molecule FISH, histological staining, confocal microscopy
· PhD in neuroscience, biology or a closely related field
· Excellent organizational and communication skills
Special Knowledge, Skills, and Abilities:
Experience with the following topics or techniques is beneficial:
· 10x Genomics single-cell or spatial platforms
· RNA-seq analysis using R/BioConductor packages
· Circuit manipulation studies in rodent models
· Signal or image processing in MATLAB or Python
- Remaining in a seated or standing position for extended periods of time;
- Reaching and grasping to manipulate objects with fingers;
- Mobility, including the ability to maneuver around a laboratory setting including the ability to move materials weighing up to 25 pounds;
- Communication skills using the spoken and written word;
- Having the ability to receive detailed information through oral communication;
- All other physical demands in a standard laboratory environment.
** If accommodations are needed due to pregnancy or a disability, please contact email@example.com
EEOC Statement: At the Lieber Institute, we are committed to a work environment of mutual respect where employment decisions are based on merit. As an equal opportunity employer, the Lieber Institute does not discriminate in employment opportunities on the basis of race, color, religion, color, sex, gender identity/expression, sexual orientation, pregnancy, marital status, age, national origin or ancestry, citizenship, disability (physical or mental), genetic information, military service, or other non-merit based factors protected by state or federal law or local ordinance, with regard to any position or employment for which the applicant or employee is qualified. PM21